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Influence of drug properties on loadings and release kinetics of drugs from silica aerogels loaded in supercritical CO<inf>2</inf>
Journal
Journal of Supercritical Fluids
ISSN
08968446
Date Issued
2022-02-01
Author(s)
Singh, Neha
Vinjamur, Madhu
Mukhopadhyay, Mamata
Abstract
The present work investigates influence of drug properties on drug loadings in silica aerogels from supercritical carbon dioxide (scCO2) and their release. Benzoic acid (BA) and fenofibrate (FF) with different molecular mass and solubilities in water and scCO2 are selected as drugs for comparison of loadings by two modes: adsorption and adsorption plus precipitation, in pores and on outer surface of aerogels. Modeling of precipitation during depressurization predicts lower nucleation rates for FF due to its higher molecular mass and higher growth rates due to its higher supersaturation compared to BA. Higher drug solubility in scCO2 facilitates higher loadings by adsorption and precipitation. Experiments confirm that larger amounts of FF adsorb and precipitate compared to BA; precipitation occurs mostly on the outer surface of aerogels, in much shorter time than adsorption. The precipitated drugs are amorphous and release much faster than crystalline forms, though FF releases slower than BA.
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