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Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties
Journal
Journal of Chemical Sciences
ISSN
09743626
Date Issued
2022-06-01
Author(s)
Kotha, Sambasivarao
Gaikwad, Vidyasagar
Abstract
We report a simple synthetic approach to N-methyl spiro hydantoin and thiazolidine containing amino acid derivatives by coupling 1,2,4,5-tetrakis(bromomethyl) benzene with ethyl isocyanoacetate (EICA) as a glycine equivalent. Normally, α-amino acids are derived from hydantoin, here we have incorporated hydantoin and amino acid moieties in the same molecules. Access to such hybrid molecules opens up new possibilities in medicinal chemistry. Graphical abstract: Herein, we developed a facile synthetic strategy to spiro hydantoin and thiazolidine derivatives bearing unusual amino acid skeleton through the coupling of 1,2,4,5-tetrakis(bromomethyl) benzene with ethyl isocyanoacetate (EICA) as a glycine equivalent. [Figure not available: see fulltext.].
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