Options
The Role of Copper Salts and O<inf>2</inf> in the Mechanism of C≡N Bond Activation for Facilitating Nitrogen Transfer Reactions**
Journal
Angewandte Chemie - International Edition
ISSN
14337851
Date Issued
2022-03-21
Author(s)
Ghosh, Boyli
Banerjee, Ambar
Roy, Lisa
Manna, Rabindra Nath
Nath, Rounak
Paul, Ankan
Abstract
C≡N bond scission can be a potential avenue for the functionalization of chemical bonds. We have conducted a computational study, using density functional theory (DFT) and ab initio multireference CASSCF methods, to unravel the intricate mechanistic pathways traversed in the copper-promoted, dioxygen-assisted reaction for the formation of aryl isocyanate species from aryl aldehyde. This aryl isocyanate species acts as an active species for C≡N bond cleavage of coordinated cyanide anion enabling nitrogen transfer to various aldehydes. Electronic structure analysis revealed that under all the reaction conditions radical-based pathways are operative, which is in agreement with the experimental findings. The major driving force is a CuII/I redox cycle initiated by single-electron transfer from the carbon center of the nitrile moiety. Our study reveals that the copper salts act as the “electron pool” in this unique nitrogen transfer reaction forming an aryl isocyanate species from aryl aldehydes.
Subjects