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Herbal bioenhancers in nanoparticulate drug delivery system
Journal
Drug Delivery Technology: Herbal Bioenhancers in Pharmaceuticals
Date Issued
2022-03-21
Author(s)
Rajput, Amarjitsing
Mandlik, Satish
Dawre, Shipa
Mandlik, Deepa
Pingale, Prashant
Butani, Shital
Abstract
Herbal bioenhancer compounds are capable of promoting and improving biological activity - the bioavailability and bioefficacy of a particular material or nutrient at low doses. They could decrease the dose of the active component and adverse effects associated with it. However, the combined use of both drugs with bioenhancer served as an economical and feasible approach too. Nowadays, researchers are diverting their research in identifying novel bioenhancers from the natural origin for drug substances with low bioavailability or significant adverse effects. Current research has indicated that several herbal components like piperine, genistein, naringin, sinomenine, glycyrrhizin, quercetin, and nitrile glycoside were capable of improving the bioavailability of certain therapeutic compounds and phytopharmaceuticals through the alteration of metabolic and intestinal absorption. Bioenhancers are also used in several nanocarrier systems such as solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsion, microemulsion, liposomes, transferosomes, ethosomes, methosomes, and sphingosomes to improve their properties, especially bioavailability. Thus, bioenhancers play a vital role in nanotechnology by enhancing the bioavailability of several components due to their inherent property.