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High-density diffuse correlation tomography with enhanced depth localization and minimal surface artefacts
Journal
Biomedical Optics Express
Date Issued
2022-11-01
Author(s)
Paul, Ria
Murali, K.
Varma, Hari M.
Abstract
A spatially weighted filter applied to both the measurement and the Jacobian is proposed for high-density diffuse correlation tomography (DCT) to remove unwanted extracerebral interferences and artefacts along with better depth localization in the reconstructed blood flow images. High-density DCT is implemented by appropriate modification of recently introduced Multi-speckle Diffuse Correlation Spectroscopy (M-DCS) system. Additionally, we have used autocorrelation measurements at multiple delay-times in an iterative manner to improve the reconstruction results. The proposed scheme has been validated by simulations, phantom experiments and in-vivo human experiments.