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Small Peptidic Ionophore for Calcium Transport
Journal
Bioconjugate Chemistry
ISSN
10431802
Date Issued
2022-11-16
Author(s)
Saha, Parichita
Basak, Debajyoti
Biswas, Sayantan
More, Priyanka A.
Madhavan, Nandita
Abstract
Synthetic calcium transporters are few despite their potential biological significance. Herein, we report small alanine-derived peptides containing pyridyl-triazole motifs for inducing calcium selectivity. The peptides are decorated with hydrophobic alkyl chains to facilitate membrane insertion. The most efficient peptide scaffold has an EC50value of 0.09 mol % and functions as a calcium carrier.