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Investigation on high-valent iron complex mediated organic transformations: Reactivity and mechanistic impact
Journal
Advances in Inorganic Chemistry
ISSN
08988838
Date Issued
2023-01-01
Author(s)
Roy, Triptesh Kumar
Suresh, Adhya
Sinha, Arka
Biswas, Jyoti Prasad
Maiti, Debabrata
Abstract
Enzymes have the unique ability to catalyze an organic transformation with unmatchable stereo- and regioselectivity and thus chemists try to mimic the active sites of different enzymes to get a proper insight into their reactivity and mechanism. In biomimetic studies, iron containing complexes are well explored and most of the iron containing enzymes utilize high-valent states (+ IV and + V) to accomplish an extensive array of reactions such as hydroxylation, dihydroxylation, epoxidation, aziridination, and halogenation. Nonheme type of ligands containing iron complexes can perform oxidation reactions where iron(IV)-oxo species are found to be key intermediates. In this chapter, we have discussed our exploration regarding the effect of ligand backbone and substrates on nonheme Fe(IV)-oxo-mediated oxygen transfer reactions; how to overcome hydroxylation reactions to achieve selective halogenation and the proper mechanistic pathway for high-valent nonheme imido-iron mediated aziridination reactions.
Volume
81
Subjects