1,2,3-Oxadiazines and 1,2,3-Thiadiazines

Structural importance, synthesis and application of 1,2,3-oxadiazines and 1,2,3-thiadiazines and their benzo-derivatives have been discussed in the present article. An elaborate spectral analysis of nocuolin A, a naturally occurring dihydrooxazine derivative from cyanobacteria, has been reported. Syntheses and reactions of benzothiadiazine 1,1-dioxide derivatives involving mainly directed o-metalation and cyclocondensation strategies have also been reported. Design, and synthesis of a camphor derived chiral organocatalyst, known as camphor sulphonylhydrazine (CaSH) and its application in enantioselective transformations have also been discussed. Finally, biological activity of nocuolin A and its derivatives, as potential antibacterial and anticancer agents along with anxiolytic property of few benzothiadiazine-1,1-dioxide analogues have also been described.