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Fabrication of Carboxymethylcellulose-Gelatin Dissolving Microneedle Patch for Pain-Free, Efficient, and Controlled Transdermal Delivery of Insulin
Journal
Journal of Pharmaceutical Innovation
ISSN
18725120
Date Issued
2023-06-01
Author(s)
Jana, Baishali A.
Osmani, Riyaz Ali
Jaiswal, Sanket
Banerjee, Rinti
Karri, Veera Venkata Satyanarayana Reddy
Wadhwani, Ashish
Abstract
Purpose: Dissolving microneedle patches are attracting attention as they are associated with improved patient compliance and safety. Methods: This study fabricated dissolving microneedle (DMN) patches from modified sodium carboxymethylcellulose (CMC) and gelatin might be as an alternative to subcutaneous injection for the transdermal delivery of insulin. Results: The prepared DMNs exhibited excellent mechanical strength to penetrate the skin and confocal microscopy showed gradual diffuse from the puncture sites to deeper tissue up to more than 750–800 µm. The in vitro study was performed by a dissolution apparatus and ex vivo by the Franz diffusion cell system mainly quantified by human insulin ELISA kit where the release study exhibited excellent results with constant and stable delivery up to 96 ± 2%. The in vivo study results confirmed an ideal drug release profile up to 95 ± 2% until 8 h in 24-h study and thus insulin-loaded CMC-gelatin formulation is suitable for drug encapsulation, having excellent dissolving factor and penetration depth and avoiding drug loss. A home applicator played an important role in improving the efficacy and stability and faster insulin release rate. The plasma insulin level and blood glucose level (BGL) were calculated and were maintained and a stable decrease in 3–4 h was observed compared to SC injection route with the same insulin dose. Conclusion: These results suggest that the CMC-gelatin DMN patch loaded with insulin has great potential in diabetes treatment for both type 1 and 2 diabetic patients in a relatively painless, rapid, and convenient manner. Graphical Abstract: [Figure not available: see fulltext.]
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