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Ni-Catalyzed Regioselective C-5 Halogenation of 8-Aminoquinoline and Co-Catalyzed Chelation Assisted C−H Iodination of Aromatic Sulfonamides with Molecular Iodine
Journal
Chemistry - An Asian Journal
ISSN
18614728
Date Issued
2022-12-01
Author(s)
Fernandes, Rodney A.
Choudhary, Priyanka
Abstract
A Ni(II)- and Co(II)-catalyzed sequential iodination of sulfonamides using inexpensive and milder molecular iodine (I2) as an iodinating reagent is reported for the first time. The 8-amino-5-iodoquinoline moiety prepared via nickel catalysis act as a directing group for second iodination by chelation assisted cobalt catalysis resulting in ortho-iodinated arylsulfonamide products. This methodology has been elaborated to various value added products by coupling reactions.
Subjects