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Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes
Journal
Chemical Communications
ISSN
13597345
Date Issued
2022-01-18
Author(s)
Kori, Santosh
Bhujbal, Yuvraj
Vadagaonkar, Kamlesh
Kapdi, Anant R.
Kommyreddy, Saidurga Prasad
Gharpure, Santosh J.
Abstract
A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents, PMX-610 and CJM-126 (precursor).