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SYNTHETIC APPROACHES TO SPIRO BIS-THF NATURAL PRODUCTS: CEPHALOSPOROLIDES, PENISPOROLIDES, ASCOSPIROKETALS AND PYRENOLIDES
Journal
Targets in Heterocyclic Systems
ISSN
17249449
Date Issued
2021-01-01
Author(s)
Fernandes, Rodney A.
Gangani, Ashvin J.
Chandra, Naveen
Abstract
The γ-lactone fused bis-THF natural products are derived from various marine sources and are known for different bioactivities. The rigid tetrahydro-spirofurofuranone moiety is present in cephalosporolides E, F, H and I, penisporolides A and B and ascospiroketal B. The related ascospiroketal A and pyrenolides have THF ring instead of the furanone, while the latter has the butenolide moiety as well. These marine-derived fungus molecular architectures have attracted much attention of the synthetic community with various interesting approaches being documented in the literature. The total synthesis of some of them have clarified the need of structure revision and all these synthetic attempts are compiled in this chapter
Volume
25