Toxicogenomics in drug safety assessment

Toxicogenomics is the study of toxicity evaluation using a combination of genomics, bioinformatics, and other high-throughput techniques. It helps in the drug development process by evaluating the risk assessment to enhance the speed of the process and to decrease the chances of drug failure at later stages. In this regard, different bioinformatics tools are being developed for evaluating toxicogenomics, and by employing these tools, a variety of toxicities can be understood upon genomic modifications. This chapter reviews toxicogenomics alterations and different methods of detecting the genomic modifications upon chemical or environmental pollutant exposure.