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Coupling of Mechanical Deformation and Electrophysiology of Brain Neuron Cell
Journal
Lecture Notes in Mechanical Engineering
ISSN
21954356
Date Issued
2022-01-01
Author(s)
Jangid, Rahul
Haldar, Krishnendu
Abstract
Traumatic brain injury (TBI), due to a vicious head impact in motor or space vehicle accidents, falls, and sports injuries, causes severe tissue deformation. The impact forces make the brain tissue distorted, twisted, and injured. Due to the impact, the stress inhomogeneity creates highly nonuniform strains and deforms the axons in the white matter. For more than half a century, electrophysiology of brain neurons was considered pure electrical phenomenon. However, recent experimental studies show that mechanical deformation plays a vital role in brain neuron’s electrophysiology. In this work, we model the finite deformation-based coupling of mechanical deformation with the Hodgkin-Huxley (H-H) model of neuron electrophysiology. The sensitivity of stretching on the membrane potential and the generated electrical field is demonstrated.
Subjects