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Kinetic and Dynamic Kinetic Resolution by Dual Catalysis
Journal
European Journal of Organic Chemistry
ISSN
1434193X
Date Issued
2022-11-25
Author(s)
Thejashree, Gangavara L.
Doris, Eric
Gravel, Edmond
Namboothiri, Irishi N.N.
Abstract
Kinetic resolution is one of the most common methods to access enantiomerically enriched compounds. In this method, the resolution is based on the existing difference in reaction rates of the two enantiomers with a chiral catalyst. In the dynamic kinetic resolution, the less reactive enantiomer is racemized and the racemic mixture is further resolved, leading eventually to complete transformation to an enantioenriched compound. This review summarizes the dual catalytic strategies (i. e., modular combinations of distinct catalysts) that have been applied to kinetic resolution and dynamic kinetic resolution. We focus upon the role of the two catalysts, the compatibility between them, and the practical benefits.
Subjects