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Synthesis and Self-Assembly of Amphiphilic Ferrocene-Selenopeptide Conjugates
Journal
European Journal of Organic Chemistry
ISSN
1434193X
Date Issued
2022-02-11
Author(s)
Maurya, Shakti K.
Swaroop Pathak, Sushil
Panchakarla, Leela S.
Singh, Harkesh B.
Abstract
Ferrocene (Fc) conjugated selenopeptides were synthesized using a new modified solid-phase peptide synthesis (SPSS) protocol and their self-assembled nanostructure formation into spheres, nanofibers, and nanotubes studied. Four selenopeptide conjugates have been successfully prepared: two containing both selenocysteine (Sec) and Fc, the other two have either one of these units. These compounds were well-characterized with various spectroscopic techniques, including 1D and 2D NMR. The importance of the Fc unit, aromatic moieties, and weak intermolecular interactions on the self-assembled process was revealed by systematic morphological studies.
Subjects