Total Synthesis of Chatenaytrienins-1, -3 and -4 and Muridienins-1-4 Enabled by C(sp)-C(sp ³) Sonogashira Coupling

Concise and efficient protecting-group-free total syntheses of chatenaytrienins-1, -3, -4 and muridienins-1 4 have been achieved. The key steps involve ring-closing metathesis (RCM) and C(sp) C(sp3)- Sonogashira coupling. This work reports the first total syntheses of chatenaytrienin-3 and muridienins-1 4 in seven linear steps and high overall yields.