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Selectivity: A Goal for Synthetic Economy
Journal
Synlett
ISSN
09365214
Date Issued
2023-04-04
Author(s)
Kotha, Sambasivarao
Ansari, Saima
Gupta, Naveen Kumar
Abstract
Chemical reactivity plays a major role in understanding several aspects of selectivity. Therefore, in this account, we present a plethora of reactions that demonstrate our efforts in exploiting interesting cases of selectivity over the past three decades. Among them, chemoselectivity, regioselectivity and stereoselectivity are discussed. Strain, steric factors, and separation of the reacting functionalities are revealed as prominent features in generating selectivity. 1 Introduction 2 Chemoselectivity 3 Regioselectivity 4 Diastereoselectivity 5 Substrate-Based Selectivity 6 Reagent-Based Selectivity 7 Steric-Volume-Induced Selectivity 8 Role of Temperature and Reaction Time in Achieving Selectivity 9 Role of the Catalyst in Observing Selectivity 10 Separation as a Parameter for Selectivity 11 pKa (Acidity of the Active Methylene Component) 12 Sequence as a Tool for Selectivity 13 Strain of the Ring System 14 Examples of Miscellaneous Selectivity 15 Conclusions
Subjects