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Late-stage Modification of Cage Diones by Tandem Metathesis
Journal
Chemistry - An Asian Journal
ISSN
18614728
Date Issued
2023-01-03
Author(s)
Kotha, Sambasivarao
Mehta, Gulazarahind
Abstract
Herein, we report the application of tandem ring-opening cross-metathesis (ROCM) and tandem ring-opening cross-metathesis followed by cross-metathesis (ROCM/CM) in highly strained diastereomeric heptacyclic cage diones (HCCD's) catalyzed by ruthenium catalysts. These caged diastereomeric compounds have a high degree of ring strain as well as steric congestion. Therefore, the present work related to ROCM is unique and intricate as compared to simple norbornene derivatives. It is useful to prepare new hexacyclic cage derivatives suitable for high-energy density materials. The synthetic strategy of starting cage compounds features the Diels-Alder reaction, and [2+2] photocycloaddition as key steps.
Subjects